Dexamethasone suppresses long QT phenotype in patient with acute promyelocytic leukemia treated with arsenic
نویسندگان
چکیده
Introduction Arsenic trioxide has recently been found to improve survival and complete response when added to all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). However, dose-limiting toxicity in the form of druginduced QT prolongation limits its use in a significant percentage of patients. Preclinical models of long QT syndrome (LQTS) have demonstrated that glucocorticoids can significantly shorten the duration of the cardiac action potential. However, the relevance of these findings is unclear in human populations. Here we report the protective effects of glucocorticoid administration on QT interval in a case of APL treated with arsenic trioxide.
منابع مشابه
Risk/benefit profile of arsenic trioxide.
Approximately 20%-30% of patients with acute promyelocytic leukemia (APL) who are treated with the current standard all-trans retinoic acid and anthracycline-based chemotherapy regimen suffer relapse. In the mid-1990s, studies from China reported the effective use of arsenic trioxide in achieving complete remission in patients with APL. In the United States, a multicenter trial of this agent in...
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